pbc.arff

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Description

Data recorded from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984.
File contents

%
% !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
%
% Case number deleted. X treated as the class attribute.
%
% As used by Kilpatrick, D. & Cameron-Jones, M. (1998). Numeric prediction
% using instance-based learning with encoding length selection. In Progress
% in Connectionist-Based Information Systems. Singapore: Springer-Verlag.
%
% !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
%
% NAME:  PBC Data
% SIZE:  418 observations, 20 variables
% 
% 
% 
% DESCRIPTIVE ABSTRACT:
% 
% Below is a description of the variables recorded from the Mayo Clinic trial 
% in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 
% 1984.  A total of 424 PBC patients, referred to Mayo Clinic during
% that ten-year interval, met eligibility criteria for the randomized placebo 
% controlled trial of the drug D-penicillamine. The first 312 cases in the data 
% set participated in the randomized trial, and contain largely complete data. 
% The additional 112 cases did not participate in the clinical trial, but 
% consented to have basic measurements recorded and to be followed for survival.
% Six of those cases were lost to follow-up shortly after diagnosis, so there 
% are data here on an additional 106 cases as well as the 312 randomized 
% participants. Missing data items are denoted by ".".  At least one space 
% separates each variable in the .DAT file.  Censoring was due to liver 
% transplantation for twenty-five subjects with the following case numbers: 
% 5, 105, 111, 120, 125, 158, 183, 241, 246, 247, 254, 263, 264, 265, 274, 
% 288, 291, 295, 297, 345, 361, 362, 375, 380, 383.
% 
% 
% 
% SOURCE:  Counting Processes and Survival Analysis by T. Fleming & 
%          D. Harrington, (1991),  published by John Wiley & Sons.
% 
% 
% 
% VARIABLE DESCRIPTIONS:
% 
% The data are in free format.  That is, at least one blank space separates
% each variable.  The variables contained in the .DAT are:
% 
% 
% N:   Case number.
% X:   The number of days between registration and the earlier of
%      death, liver transplantation, or study analysis time in July, 1986.
% D:   1 if X is time to death, 0 if time to censoring
% Z1:  Treatment Code, 1 = D-penicillamine, 2 = placebo.
% Z2:  Age in years. For the first 312 cases, age was calculated by
%      dividing the number of days between birth and study registration by 365.
% Z3:  Sex, 0 = male, 1 = female.
% Z4:  Presence of ascites, 0 = no, 1 = yes.
% Z5:  Presence of hepatomegaly, 0 = no, 1 = yes.
% Z6:  Presence of spiders 0 = no, 1 = Yes.
% Z7:  Presence of edema, 0 = no edema and no diuretic therapy for
%      edema; 0.5 = edema present for which no diuretic therapy was given, or 
%      edema resolved with diuretic therapy; 1 = edema despite diuretic therapy
% Z8:  Serum bilirubin, in mg/dl.
% Z9:  Serum cholesterol, in mg/dl.
% Z10: Albumin, in gm/dl.
% Z11: Urine copper, in mg/day.
% Z12: Alkaline phosphatase, in U/liter.
% Z13: SGOT, in U/ml.
% Z14: Triglycerides, in mg/dl.
% Z15: Platelet count; coded value is number of platelets
%      per-cubic-milliliter of blood divided by 1000.
% Z16: Prothrombin time, in seconds.
% Z17: Histologic stage of disease, graded 1, 2, 3, or 4.
% 
% 
% 
% 
% STORY BEHIND THE DATA:
% 
% Between January, 1974 and May, 1984, the Mayo Clinic conducted a
% double-blinded randomized trial in primary biliary cirrhosis of the liver
% (PBC), comparing the drug D-penicillamine (DPCA) with a placebo. There
% were 424 patients who met the eligibility criteria seen at the Clinic while
% the trial was open for patient registration. Both the treating physician and
% the patient agreed to participate in the randomized trial in 312 of the 424
% cases. The date of randomization and a large number of clinical, biochemical,
% serologic, and histologic parameters were recorded for each of the 312
% clinical trial patients. The data from the trial were analyzed in 1986 for
% presentation in the clinical literature. For that analysis, disease and 
% survival status as of July, 1986, were recorded for as many patients as 
% possible.  By that date, 125 of the 312 patients had died, with only 11 
% not attributable to PBC.  Eight patients had been lost to follow up, and 19 
% had undergone liver transplantation. 
% 
% PBC is a rare but fatal chronic liver disease of unknown cause,
% with a prevalence of about 50-cases-per-million population. The primary
% pathologic event appears to be the destruction of interlobular bile ducts,
% which may be mediated by immunologic mechanisms. The data discussed here are
% important in two respects. First, controlled clinical trials are difficult to
% complete in rare diseases, and this case series of patients uniformly
% diagnosed, treated, and followed is the largest existing for PBC. The
% treatment comparison in this trial is more precise than in similar trials
% having fewer participants and avoids the bias that may arise in comparing
% a case series to historical controls. Second, the data present an
% opportunity to study the natural history of the disease. We will see that, 
% despite the immunosuppressive properties of DPCA, there are no detectable
% differences between the distributions of survival times for the DPCA and
% placebo treatment groups. This suggests that these groups can be combined
% in studying the association between survival time from randomization and
% clinical and other measurements. In the early to mid 1980s, the rate of 
% successful liver transplant increased substantially, and transplant has 
% become an effective therapy for PBC. The Mayo Clinic data set is therefore 
% one of the last allowing a study of the natural history of PBC in patients 
% who were treated with only supportive care or its equivalent. The PBC data 
% can be used to: estimate a survival distribution; test for differences 
% between two groups; and estimate covariate effects via a regression
% model.
% 
@relation 'pbc'
@attribute D { 1, 0}
@attribute Z1 { 1, 2}
@attribute Z2 real
@attribute Z3 { 1, 0}
@attribute Z4 { 1, 0}
@attribute Z5 { 1, 0}
@attribute Z6 { 1, 0}
@attribute Z7 { 1, 0, 0.500000}
@attribute Z8 real
@attribute Z9 real
@attribute Z10 real
@attribute Z11 real
@attribute Z12 real
@attribute Z13 real
@attribute Z14 real
@attribute Z15 real
@attribute Z16 real
@attribute Z17 { 4, 3, 2, 1}
@attribute class real
@data
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1,2,41.5524,1,0,1,0,0,4.7,296,3.44,114,9933.2,206.4,101,195,10.3,2,3839
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1,1,65.8836,1,1,0,0,1,17.9,175,2.1,220,705,338,229,62,12.9,4,41
0,2,33.9439,1,0,1,0,0,1.3,304,3.52,97,1622,71,169,255,9.5,4,1455
0,2,62.8611,1,0,0,0,0,1.1,412,3.99,103,1293,91,113,422,9.6,4,1030
0,2,48.564,1,0,0,0,0,1.3,291,3.44,75,1082,85,195,251,9.5,3,1418
0,1,46.3491,1,0,0,0,0,0.8,253,3.48,65,688,57,80,252,10,1,1401
0,1,38.8528,1,0,1,1,0,2,310,3.36,70,1257,122,118,143,9.8,3,1408
0,1,58.6475,1,0,0,1,0,6.4,373,3.46,155,1768,120,151,258,10.1,4,1234
0,2,48.9363,1,0,1,0,0.500000,8.7,310,3.89,107,637,117,242,298,9.6,2,1067
1,1,67.5729,0,0,1,0,0.500000,4,416,3.99,177,960,86,242,269,9.8,2,799
0,1,65.9849,1,0,0,0,0,1.4,294,3.57,33,722,93,69,283,9.8,3,1363
0,1,40.9008,1,0,0,0,0,3.2,339,3.18,123,3336,205,84,304,9.9,4,901
0,2,50.245,0,0,1,0,0,8.6,546,3.73,84,1070,127,153,291,11.2,3,1329
0,2,57.1964,1,0,1,1,1,8.5,194,2.98,196,815,163,78,122,12.3,4,1320
0,1,60.5366,0,0,1,0,0,6.6,1000,3.07,88,3150,193,133,299,10.9,4,1302
0,1,35.3511,0,0,0,0,0,2.4,646,3.83,102,855,127,194,306,10.3,3,877
0,2,31.3812,1,0,0,0,0,0.8,328,3.31,62,1105,137,95,293,10.9,4,1321
0,1,55.9863,0,0,1,0,0,1.2,275,3.43,100,1142,75,91,217,11.3,4,533
0,2,52.7255,1,0,1,0,0,1.1,340,3.37,73,289,97,93,243,10.2,3,1300
0,1,38.0917,1,0,0,0,0,2.4,342,3.76,90,1653,150,127,213,10.8,3,1293
1,2,58.1711,1,0,1,0,0,5.2,?,2.23,234,601,135,?,206,12.3,4,207
0,2,45.2101,1,0,0,0,0,1,393,3.57,50,1307,74,103,295,10.5,4,1295
0,1,37.7988,1,0,0,0,0,0.7,335,3.95,43,657,52,104,268,10.6,2,1271
0,2,60.6598,1,0,1,1,0,1,372,3.25,108,1190,140,55,248,10.6,4,1250
0,1,35.5346,1,0,0,0,0,0.5,219,3.93,22,663,45,75,246,10.8,3,1230
0,2,43.0664,1,0,1,1,0,2.9,426,3.61,73,5184,288,144,275,10.6,3,1216
0,2,56.3915,1,0,1,0,0,0.6,239,3.45,31,1072,55,64,227,10.7,2,1216
0,2,30.5736,1,0,0,0,0,0.8,273,3.56,52,1282,130,59,344,10.5,2,1149
0,1,61.1828,1,0,1,0,0,0.4,246,3.58,24,797,91,113,288,10.4,2,1153
0,2,58.2998,1,0,0,0,0,0.4,260,2.75,41,1166,70,82,231,10.8,2,994
0,1,62.3326,1,0,0,0,0,1.7,434,3.35,39,1713,171,100,234,10.2,2,939
0,1,37.9986,1,0,0,0,0,2,247,3.16,69,1050,117,88,335,10.5,2,839
0,2,33.1526,1,0,0,1,0,6.4,576,3.79,186,2115,136,149,200,10.8,2,788
0,?,60,?,?,?,?,0,0.7,?,3.65,?,?,?,?,378,11,?,4062
1,?,65,?,?,?,?,0.500000,1.4,?,3.04,?,?,?,?,331,12.1,?,3561
0,?,54,?,?,?,?,0,0.7,?,4.03,?,?,?,?,226,9.8,?,2844
1,?,75,?,?,?,?,0.500000,0.7,?,3.96,?,?,?,?,?,11.3,?,2071
0,?,62,?,?,?,?,0,0.8,?,2.48,?,?,?,?,273,10,?,3030
0,?,43,?,?,?,?,0,0.7,?,3.68,?,?,?,?,306,9.5,?,1680
1,?,46,?,?,?,?,0,5,?,2.93,?,?,?,?,260,10.4,?,41
0,?,44,?,?,?,?,0.500000,0.4,?,3.81,?,?,?,?,226,10.5,?,2403
0,?,61,?,?,?,?,0.500000,1.3,?,3.41,?,?,?,?,259,10.9,?,1170
1,?,64,?,?,?,?,0,1.1,?,3.69,?,?,?,?,139,10.5,?,2011
0,?,40,?,?,?,?,0,0.6,?,4.04,?,?,?,?,130,11.2,?,3523
0,?,63,?,?,?,?,0,0.6,?,3.94,?,?,?,?,234,11.5,?,3468
0,?,34,?,?,?,?,0,1.8,?,3.24,?,?,?,?,?,18,?,4795
0,?,52,?,?,?,?,0,1.5,?,3.42,?,?,?,?,246,10.3,?,1236
0,?,49,?,?,?,?,0,1.2,?,3.99,?,?,?,?,?,11.2,?,4214
1,?,54,?,?,?,?,0,1,?,3.6,?,?,?,?,?,12.1,?,2111
1,?,63,?,?,?,?,0,0.7,?,3.4,?,?,?,?,371,10.1,?,1462
1,?,54,?,?,?,?,0,3.5,?,3.63,?,?,?,?,325,10.3,?,1746
1,?,46,?,?,?,?,0.500000,3.1,?,3.56,?,?,?,?,142,13.6,?,94
1,?,53,?,?,?,?,0,12.6,?,2.87,?,?,?,?,114,11.8,?,785
1,?,56,?,?,?,?,0,2.8,?,3.92,?,?,?,?,?,10.6,?,1518
1,?,56,?,?,?,?,0,7.1,?,3.51,?,?,?,?,721,11.8,?,466
0,?,55,?,?,?,?,0,0.6,?,4.15,?,?,?,?,280,10.1,?,3527
0,?,65,?,?,?,?,0,2.1,?,3.34,?,?,?,?,155,10.1,?,2635
1,?,56,?,?,?,?,0,1.8,?,3.64,?,?,?,?,141,10,?,2286
1,?,47,?,?,?,?,0,16,?,3.42,?,?,?,?,475,13.8,?,791
0,?,60,?,?,?,?,0,0.6,?,4.38,?,?,?,?,269,10.6,?,3492
0,?,53,?,?,?,?,0,5.4,?,4.19,?,?,?,?,141,11.2,?,3495
1,?,54,?,?,?,?,0,9,?,3.29,?,?,?,?,286,13.1,?,111
0,?,50,?,?,?,?,0,0.9,?,4.01,?,?,?,?,244,10.5,?,3231
1,?,48,?,?,?,?,0,11.1,?,2.84,?,?,?,?,?,12.2,?,625
0,?,36,?,?,?,?,0,8.9,?,3.76,?,?,?,?,209,10.6,?,3157
0,?,48,?,?,?,?,0,0.5,?,3.76,?,?,?,?,388,10.1,?,3021
1,?,70,?,?,?,?,0.500000,0.6,?,3.81,?,?,?,?,160,11,?,559
1,?,51,?,?,?,?,0,3.4,?,3.92,?,?,?,?,?,9.3,?,2812
0,?,52,?,?,?,?,0,0.9,?,3.14,?,?,?,?,191,12.3,?,2834
0,?,54,?,?,?,?,0,1.4,?,3.82,?,?,?,?,249,10.3,?,2855
1,?,48,?,?,?,?,0,2.1,?,4.1,?,?,?,?,200,9,?,662
1,?,66,?,?,?,?,0,15,?,3.4,?,?,?,?,150,11.1,?,727
0,?,53,?,?,?,?,0,0.6,?,4.19,?,?,?,?,330,9.9,?,2716
0,?,62,?,?,?,?,0,1.3,?,3.4,?,?,?,?,167,10.6,?,2698
1,?,59,?,?,?,?,0,1.3,?,3.12,?,?,?,?,125,9.6,?,990
0,?,39,?,?,?,?,0,1.6,?,3.75,?,?,?,?,145,10.4,?,2338
1,?,67,?,?,?,?,0.500000,2.2,?,3.26,?,?,?,?,171,11.1,?,1616
0,?,58,?,?,?,?,0,3,?,3.46,?,?,?,?,109,10.4,?,2563
0,?,64,?,?,?,?,0,0.8,?,3.49,?,?,?,?,314,10.3,?,2537
0,?,46,?,?,?,?,0,0.8,?,2.89,?,?,?,?,419,?,?,2534
1,?,64,?,?,?,?,0,1.8,?,3.15,?,?,?,?,183,10.4,?,778
0,?,41,?,?,?,?,0,5.5,?,2.31,?,?,?,?,517,10.4,?,617
0,?,49,?,?,?,?,0,18,?,3.04,?,?,?,?,432,9.7,?,2267
0,?,44,?,?,?,?,0,0.6,?,3.5,?,?,?,?,150,9.9,?,2249
1,?,59,?,?,?,?,0,2.7,?,3.35,?,?,?,?,142,11.5,?,359
0,?,63,?,?,?,?,0,0.9,?,3.58,?,?,?,?,224,10,?,1925
1,?,61,?,?,?,?,0,1.3,?,3.01,?,?,?,?,223,10.7,?,249
0,?,64,?,?,?,?,0,1.1,?,3.49,?,?,?,?,166,9.8,?,2202
1,?,49,?,?,?,?,0,13.8,?,2.77,?,?,?,?,388,?,?,43
1,?,42,?,?,?,?,0,4.4,?,4.52,?,?,?,?,102,10.8,?,1197
1,?,50,?,?,?,?,0,16,?,3.36,?,?,?,?,384,10,?,1095
1,?,51,?,?,?,?,0.500000,7.3,?,3.52,?,?,?,?,265,11.1,?,489
0,?,37,?,?,?,?,0,0.6,?,3.55,?,?,?,?,248,10.3,?,2149
0,?,62,?,?,?,?,0,0.7,?,3.29,?,?,?,?,190,9.8,?,2103
0,?,51,?,?,?,?,0,0.7,?,3.1,?,?,?,?,274,10.6,?,1980
0,?,52,?,?,?,?,0,1.7,?,3.24,?,?,?,?,231,10.5,?,1347
1,?,44,?,?,?,?,0,9.5,?,3.63,?,?,?,?,292,10.2,?,1478
0,?,33,?,?,?,?,0,2.2,?,3.76,?,?,?,?,253,9.9,?,1987
1,?,60,?,?,?,?,0.500000,1.8,?,3.62,?,?,?,?,225,9.9,?,1168
1,?,63,?,?,?,?,0.500000,3.3,?,2.73,?,?,?,?,224,11.1,?,597
0,?,33,?,?,?,?,0,2.9,?,4.08,?,?,?,?,418,10.5,?,1725
0,?,41,?,?,?,?,0,1.7,?,3.66,?,?,?,?,92,11,?,1899
1,?,51,?,?,?,?,0,14,?,2.58,?,?,?,?,190,11.6,?,221
0,?,37,?,?,?,?,0.500000,0.8,?,3,?,?,?,?,76,10.8,?,1022
0,?,59,?,?,?,?,0,1.3,?,3.4,?,?,?,?,243,9.7,?,1639
0,?,55,?,?,?,?,0,0.7,?,2.93,?,?,?,?,209,10.6,?,1635
0,?,54,?,?,?,?,0,1.7,?,2.38,?,?,?,?,166,9.8,?,1654
0,?,49,?,?,?,?,0.500000,13.6,?,3,?,?,?,?,233,9.9,?,1653
0,?,40,?,?,?,?,0,0.9,?,3.5,?,?,?,?,117,10.9,?,1560
0,?,67,?,?,?,?,0,0.7,?,3.06,?,?,?,?,165,10,?,1581
0,?,68,?,?,?,?,0,3,?,3.15,?,?,?,?,139,10,?,1419
0,?,41,?,?,?,?,0,1.2,?,2.8,?,?,?,?,120,11,?,1443
0,?,69,?,?,?,?,0,0.4,?,3.03,?,?,?,?,173,10.9,?,1368
1,?,52,?,?,?,?,0.500000,0.7,?,2.96,?,?,?,?,319,9.9,?,193
0,?,57,?,?,?,?,0.500000,2,?,3.07,?,?,?,?,80,12.1,?,1367
0,?,36,?,?,?,?,0,1.4,?,3.98,?,?,?,?,402,11,?,1329
0,?,50,?,?,?,?,0,1.6,?,3.48,?,?,?,?,277,10.2,?,1343
0,?,64,?,?,?,?,0,0.5,?,3.65,?,?,?,?,425,10.2,?,1328
0,?,62,?,?,?,?,0,7.3,?,3.49,?,?,?,?,189,10.9,?,1375
0,?,42,?,?,?,?,0,8.1,?,2.82,?,?,?,?,193,10.4,?,1260
0,?,44,?,?,?,?,0,0.5,?,3.34,?,?,?,?,258,10.6,?,1223
1,?,69,?,?,?,?,0,4.2,?,3.19,?,?,?,?,120,11.1,?,935
0,?,52,?,?,?,?,0,0.8,?,3.01,?,?,?,?,256,10.6,?,943
0,?,66,?,?,?,?,0,2.5,?,3.33,?,?,?,?,256,10.8,?,1141
0,?,40,?,?,?,?,0,4.6,?,3.6,?,?,?,?,337,10.4,?,1092
0,?,52,?,?,?,?,0,1,?,3.64,?,?,?,?,340,10.6,?,1150
1,?,46,?,?,?,?,0,4.5,?,2.68,?,?,?,?,219,11.5,?,703
0,?,54,?,?,?,?,0,1.1,?,3.69,?,?,?,?,220,10.8,?,1129
0,?,51,?,?,?,?,0.500000,1.9,?,3.17,?,?,?,?,162,10.7,?,1086
0,?,43,?,?,?,?,0,0.7,?,3.73,?,?,?,?,214,10.8,?,1067
0,?,39,?,?,?,?,0,1.5,?,3.81,?,?,?,?,255,10.8,?,1072
0,?,51,?,?,?,?,0,0.6,?,3.57,?,?,?,?,286,10.6,?,1119
0,?,67,?,?,?,?,0,1,?,3.58,?,?,?,?,244,10.8,?,1097
0,?,35,?,?,?,?,0,0.7,?,3.23,?,?,?,?,312,10.8,?,989
1,?,67,?,?,?,?,0,1.2,?,2.96,?,?,?,?,174,10.9,?,681
0,?,39,?,?,?,?,0,0.9,?,3.83,?,?,?,?,180,11.2,?,1103
0,?,57,?,?,?,?,0,1.6,?,3.42,?,?,?,?,143,9.9,?,1055
0,?,58,?,?,?,?,0,0.8,?,3.75,?,?,?,?,269,10.4,?,691
0,?,53,?,?,?,?,0,0.7,?,3.29,?,?,?,?,350,10.6,?,976

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